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Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD

DNA methylation has recently been linked to transcriptional dysregulation and neuronal dysfunction in polyglutamine (polyQ) disease. This study aims to determine whether (CAG)(n) expansion in ATXN3 perturbs DNA methylation status and affects gene expression. We analyzed DNA methylation throughout th...

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Bibliografiska uppgifter
I publikationen:Aging (Albany NY)
Huvudupphovsmän: Ding, Dongxue, Wang, Chunrong, Chen, Zhao, Xia, Kun, Tang, Beisha, Qiu, Rong, Jiang, Hong
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906150/
https://ncbi.nlm.nih.gov/pubmed/33411688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202331
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