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Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD
DNA methylation has recently been linked to transcriptional dysregulation and neuronal dysfunction in polyglutamine (polyQ) disease. This study aims to determine whether (CAG)(n) expansion in ATXN3 perturbs DNA methylation status and affects gene expression. We analyzed DNA methylation throughout th...
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| izdano v: | Aging (Albany NY) |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Impact Journals
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7906150/ https://ncbi.nlm.nih.gov/pubmed/33411688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202331 |
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