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Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD

DNA methylation has recently been linked to transcriptional dysregulation and neuronal dysfunction in polyglutamine (polyQ) disease. This study aims to determine whether (CAG)(n) expansion in ATXN3 perturbs DNA methylation status and affects gene expression. We analyzed DNA methylation throughout th...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Ding, Dongxue, Wang, Chunrong, Chen, Zhao, Xia, Kun, Tang, Beisha, Qiu, Rong, Jiang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906150/
https://ncbi.nlm.nih.gov/pubmed/33411688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202331
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