Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants

BACKGROUND: Cell type-specific transcriptional programming results from the combinatorial interplay between the repertoire of active regulatory elements. Disease-associated variants disrupt such programming, leading to altered expression of downstream regulated genes and the onset of pathological st...

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Detalhes bibliográficos
Publicado no:BMC Biol
Main Authors: Duan, Aiping, Wang, Hong, Zhu, Yan, Wang, Qi, Zhang, Jing, Hou, Qing, Xing, Yuexian, Shi, Jinsong, Hou, Jinhua, Qin, Zhaohui, Chen, Zhaohong, Liu, Zhihong, Yang, Jingping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905576/
https://ncbi.nlm.nih.gov/pubmed/33627123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-021-00977-7
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