Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines

Fluorouracil (5FU) is converted to its active metabolite fluoro-deoxyuridine monophosphate (FdUMP) through the orotate phosphoribosyl transferase (OPRT)-ribonucleotide reductase (RR) pathway and thymidine phosphatase (TP)-thymidine kinase (TK) pathway and inhibits thymidylate synthase (TS), leading...

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Veröffentlicht in:Oncol Rep
Hauptverfasser: Suetsugu, Tomonari, Mori, Ryutaro, Futamura, Manabu, Fukada, Masahiro, Tanaka, Hideharu, Yasufuku, Itaru, Sato, Yuta, Iwata, Yoshinori, Imai, Takeharu, Imai, Hisashi, Tanaka, Yoshihiro, Okumura, Naoki, Matsuhashi, Nobuhisa, Takahashi, Takao, Yoshida, Kazuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905524/
https://ncbi.nlm.nih.gov/pubmed/33649846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2021.7978
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