The inhibition of thymidine phosphorylase can reverse acquired 5FU-resistance in gastric cancer cells

BACKGROUND: 5FU can be converted to its active metabolite fluoro-deoxyuridine monophosphate (FdUMP) through two pathways: the orotate phosphoribosyl transferase–ribonucleotide reductase (OPRT–RR) pathway and the thymidine phosphorylase–thymidine kinase (TP–TK) pathway. We investigated the mechanism...

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Dettagli Bibliografici
Pubblicato in:Gastric Cancer
Autori principali: Mori, Ryutaro, Yoshida, Kazuhiro, Futamura, Manabu, Suetsugu, Tomonari, Shizu, Kaoru, Tanahashi, Toshiyuki, Tanaka, Yoshihiro, Matsuhashi, Nobuhisha, Yamaguchi, Kazuya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Singapore 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476841/
https://ncbi.nlm.nih.gov/pubmed/30276573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10120-018-0881-3
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