Transmembrane Domain 3 (TM3) Governs Orai1 and Orai3 Pore Opening in an Isoform-Specific Manner

STIM1-mediated activation of calcium selective Orai channels is fundamental for life. The three Orai channel isoforms, Orai1-3, together with their multiple ways of interplay, ensure their highly versatile role in a variety of cellular functions and tissues in both, health and disease. While all thr...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Tiffner, Adéla, Maltan, Lena, Fahrner, Marc, Sallinger, Matthias, Weiß, Sarah, Grabmayr, Herwig, Höglinger, Carmen, Derler, Isabella
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905104/
https://ncbi.nlm.nih.gov/pubmed/33644073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.635705
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