Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma

Steroid 5α-reductase type I (SRD5A1) is a validated oncogene in many sex hormone-related cancers, but its role in multiple myeloma (MM) remains unknown. Based on gene expression profiling (GEP) of sequential MM samples during the disease course, we found that the aberrant expression of SRD5A1 was co...

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Vydáno v:Cell Death Dis
Hlavní autoři: Dou, Renjie, Qian, Jinjun, Wu, Wei, Zhang, Yanxin, Yuan, Yuxia, Guo, Mengjie, Wei, Rongfang, Yang, Shu, Jurczyszyn, Artur, Janz, Siegfried, Beksac, Meral, Gu, Chunyan, Yang, Ye
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904855/
https://ncbi.nlm.nih.gov/pubmed/33627630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03510-4
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