Notch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa

Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC), but its cellular origin and mechanism of neoplastic progression remain unresolved. Notch signaling, which plays a key role in regulating intestinal stem cell maintenance, has been implicated in a number of cancers. The kinas...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kunze, Bettina, Middelhoff, Moritz, Maurer, H. Carlo, Agibalova, Tatiana, Anand, Akanksha, Bührer, Anne-Marie, Fang, Hsin-Yu, Baumeister, Theresa, Steiger, Katja, Strangmann, Julia, Schmid, Roland M., Wang, Timothy C., Quante, Michael
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904766/
https://ncbi.nlm.nih.gov/pubmed/33627749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84011-4
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