Notch Signaling Mediates Differentiation in Barrett’s Esophagus and Promotes Progression to Adenocarcinoma

BACKGROUND & AIMS: Studies are needed to determine the mechanism by which Barrett’s esophagus (BE) progresses to esophageal adenocarcinoma (EAC). Notch signaling maintains stem cells in the gastrointestinal tract and is dysregulated during carcinogenesis. We explored the relationship between Not...

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Publicado no:Gastroenterology
Main Authors: Kunze, Bettina, Wein, Frederik, Fang, Hsin-Yu, Anand, Akanksha, Baumeister, Theresa, Strangmann, Julia, Gerland, Sophie, Ingermann, Jonas, Münch, Natasha Stephens, Wiethaler, Maria, Sahm, Vincenz, Sastre, Ana Hidalgo, Lange, Sebastian, Lightdale, Charles J, Bokhari, Aqiba, Falk, Gary W, Friedman, Richard A, Ginsberg, Gregory G, Iyer, Prasad G, Jin, Zhezhen, Nakagawa, Hiroshi, Shawber, Carrie J, Nguyen, TheAnh, Raab, William J., Dalerba, Piero, Rustgi, Anil K, Sepulveda, Antonia R, Wang, Kenneth K, Schmid, Roland M, Wang, Timothy C., Abrams, Julian A., Quante, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484392/
https://ncbi.nlm.nih.gov/pubmed/32325086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.04.033
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