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Bistable, Biphasic Regulation of PP2A-B55 Accounts for the Dynamics of Mitotic Substrate Phosphorylation

The phosphorylation of mitotic proteins is bistable, which contributes to the decisiveness of the transitions into and out of M phase. The bistability in substrate phosphorylation has been attributed to bistability in the activation of the cyclin-dependent kinase Cdk1. However, more recently it has...

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Gepubliceerd in:Curr Biol
Hoofdauteurs: Kamenz, Julia, Gelens, Lendert, Ferrell, James E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904671/
https://ncbi.nlm.nih.gov/pubmed/33357450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2020.11.058
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