Systemic Dendrimer Delivery of Triptolide to Tumor-Associated Macrophages Improves Anti-Tumor Efficacy and Reduces Systemic Toxicity in Glioblastoma

Novel delivery strategies are necessary to effectively address glioblastoma without systemic toxicities. Triptolide is a therapy derived from the thunder god vine that has shown potent anti-proliferative and immunosuppressive properties but exhibits significant adverse systemic effects. Dendrimer-ba...

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Veröffentlicht in:J Control Release
Hauptverfasser: Liaw, Kevin, Sharma, Rishi, Sharma, Anjali, Salazar, Sebastian, La Rosa, Santiago Appiani, Kannan, Rangaramanujam M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904646/
https://ncbi.nlm.nih.gov/pubmed/33290796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.12.003
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