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Nuclear deformation causes DNA damage by increasing replication stress

Cancer metastasis, i.e., the spreading of tumor cells from the primary tumor to distant organs, is responsible for the vast majority of cancer deaths. In the process, cancer cells migrate through narrow interstitial spaces substantially smaller in cross-section than the cell. During such confined mi...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Shah, Pragya, Hobson, Chad M., Cheng, Svea, Colville, Marshall J., Paszek, Matthew J., Superfine, Richard, Lammerding, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904640/
https://ncbi.nlm.nih.gov/pubmed/33326770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2020.11.037
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