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17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice

The potent estrogen 17β-estradiol (E(2)) is known to enhance hippocampal memory and plasticity, however the molecular mechanisms underlying these effects remain unclear. Brain derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) are regulated by E(2), but the pote...

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Dades bibliogràfiques
Publicat a:Psychoneuroendocrinology
Autors principals: Gross, Kellie S., Alf, Randie L., Polzin, Tiffany R., Frick, Karyn M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904635/
https://ncbi.nlm.nih.gov/pubmed/33352471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2020.105110
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