The enzyme subunit SubA of Shiga toxin-producing E. coli strains demonstrates comparable intracellular transport and cytotoxic activity as the holotoxin SubAB in HeLa and HCT116 cells in vitro

The subtilase cytotoxin (SubAB) is secreted by certain Shiga toxin-producing Escherichia coli (STEC) strains and is composed of the enzymatically active subunit SubA and the pentameric binding/transport subunit SubB. We previously demonstrated that SubA (10 µg/ml), in the absence of SubB, binds and...

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Dades bibliogràfiques
Publicat a:Arch Toxicol
Autors principals: Sessler, Katharina, Papatheodorou, Panagiotis, Wondany, Fanny, Krause, Maike, Noettger, Sabrina, Bernhard, Denise, Michaelis, Jens, Schmidt, Herbert, Barth, Holger
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2021
Matèries:
Molecular Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904543/
https://ncbi.nlm.nih.gov/pubmed/33483759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02965-2
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