Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes (T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we determined the expression of the IFN response markers MxA, PKR, and HLA-I in the islets of autoantibody-positive and T...

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Pubblicato in:Sci Adv
Autori principali: Apaolaza, Paola S., Balcacean, Diana, Zapardiel-Gonzalo, Jose, Nelson, Grace, Lenchik, Nataliya, Akhbari, Pouria, Gerling, Ivan, Richardson, Sarah J., Rodriguez-Calvo, Teresa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904254/
https://ncbi.nlm.nih.gov/pubmed/33627420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd6527
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