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Structure of Nevanimibe-bound Tetrameric Human Sterol O-acyltransferase 1
Cholesterol is physiologically indispensable for mammals, as illustrated by its abundance of up to 50% of plasma membrane lipids; in contrast, only 5% of lipids in the endoplasmic reticulum (ER) are cholesterol (1). The ER enzyme sterol O-acyltransferase 1 (also named acyl-coA:cholesterol acyltransf...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7903523/ https://ncbi.nlm.nih.gov/pubmed/32433613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2295-8 |
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