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In Vitro and In Vivo Sequestration of Phencyclidine by Me(4)Cucurbit[8]uril

We report investigations of the use of cucurbit[8]uril (CB[8]) macrocycles as an antidote to counteract the in vivo biological effects of phencyclidine. We investigate the binding of CB[8] and its derivative Me(4)CB[8] toward ten drugs of abuse (3 – 9, 12 –14) by a combination of (1)H NMR spectrosco...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Murkli, Steven, Klemm, Jared, Brockett, Adam T., Shuster, Michael, Briken, Volker, Roesch, Matthew R., Isaacs, Lyle
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902406/
https://ncbi.nlm.nih.gov/pubmed/33206421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202004380
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