Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach

VRC01 is a first-in-class, potent, broadly neutralizing antibody that targets the CD4 binding site of gp120 on HIV-1 viruses, and is under development as a novel HIV therapeutic. This study utilized population pharmacokinetic modeling to characterize VRC01 pharmacokinetics to guide dosing selection...

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Udgivet i:Clin Pharmacol Ther
Main Authors: Li, Jerry, Nikanjam, Mina, Cunningham, Coleen K., McFarland, Elizabeth J., Coates, Emily E., Houser, Katherine V., Lin, Bob C., McDermott, Adrian B., Flach, Britta, Gama, Lucio, Koup, Richard A., Graham, Barney S., Mascola, John R., Ledgerwood, Julie E., Capparelli, Edmund V.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902301/
https://ncbi.nlm.nih.gov/pubmed/32866318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2026
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