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Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters

Adeno-associated viral vectors are widely used as vehicles for gene transfer to the nervous system. The promoter and viral vector serotype are two key factors that determine the expression dynamics of the transgene. A previous comparative study has demonstrated that AAV1 displays efficient transduct...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Gene Ther
Hauptverfasser: Nieuwenhuis, Bart, Haenzi, Barbara, Hilton, Sam, Carnicer-Lombarte, Alejandro, Hobo, Barbara, Verhaagen, Joost, Fawcett, James W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902269/
https://ncbi.nlm.nih.gov/pubmed/32576975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-020-0169-1
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