The Distinct Function of p21(Waf1/Cip1) With p16(Ink4a) in Modulating Aging Phenotypes of Werner Syndrome by Affecting Tissue Homeostasis

Human Werner syndrome (WS) is an autosomal recessive progeria disease. A mouse model of WS manifests the disease through telomere dysfunction-induced aging phenotypes, which might result from cell cycle control and cellular senescence. Both p21(Waf1/Cip1) (p21, encoded by the Cdkn1a gene) and p16(In...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Zhang, Yongjin, Shao, Chihao, Li, Haili, Wu, Kun, Gong, Lixin, Zheng, Quan, Dan, Juhua, Jia, Shuting, Tang, Xiaodan, Wu, Xiaoming, Luo, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901894/
https://ncbi.nlm.nih.gov/pubmed/33633779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.597566
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