Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation

We have recently reported on an experimental model of mitochondrial mistranslation conferred by amino acid exchange V338Y in mitochondrial ribosomal protein MrpS5. Here we used a combination of RNA-seq and metabolic profiling of homozygous transgenic Mrps5(V338Y/V338Y) mice to analyze the changes as...

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Vydáno v:RNA
Hlavní autoři: Shcherbakov, Dimitri, Duscha, Stefan, Juskeviciene, Reda, Restelli, Lisa M., Frank, Stephan, Laczko, Endre, Böttger, Erik C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2021
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Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901843/
https://ncbi.nlm.nih.gov/pubmed/33262249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.077347.120
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