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Physioxia enhances T-cell development ex vivo from human hematopoietic stem and progenitor cells

Understanding physiologic T-cell development from hematopoietic stem (HSCs) and progenitor cells (HPCs) is essential for development of improved hematopoietic cell transplantation (HCT) and emerging T-cell therapies. Factors in the thymic niche, including Notch 1 receptor ligand, guide HSCs and HPCs...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Shin, Dong-Yeop, Huang, Xinxin, Gil, Chang-Hyun, Aljoufi, Arafat, Ropa, James, Broxmeyer, Hal E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901063/
https://ncbi.nlm.nih.gov/pubmed/32761664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3259
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