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The importance of hypoxia and EPHOSS for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex-vivo

PURPOSE OF REVIEW: Hematopoietic stem (HSCs), and progenitor (HPCs) cells reside in a hypoxic (lowered oxygen (O(2)) tension) environment, in vivo. We review literature on growth of HSCs and HPCs under hypoxic and normoxic (ambient air) conditions with a focus on our recent work demonstrating the de...

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Detalhes bibliográficos
Publicado no:Curr Opin Hematol
Main Authors: Broxmeyer, Hal E., O'Leary, Heather A., Huang, Xinxin, Mantel, Charlie
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721218/
https://ncbi.nlm.nih.gov/pubmed/26049746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MOH.0000000000000144
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