Doxorubicin-induced myocardial fibrosis involves the neurokinin-1 receptor and direct effects on cardiac fibroblasts

BACKGROUND: Cancer patients receiving anthracycline-based chemotherapy (Anth-bC) may experience early cardiac fibrosis, which could be an important contributing mechanism to the development of impaired left ventricular (LV) function. Substance P, a neuropeptide that predominantly acts via the neurok...

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Publicado en:Heart Lung Circ
Main Authors: Levick, Scott P., Soto-Pantoja, David R., Bi, Jianli, Hundley, W. Gregory, Widiapradja, Alexander, Manteufel, Edward J., Bradshaw, Tancia W., Meléndez, Giselle C.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901001/
https://ncbi.nlm.nih.gov/pubmed/30205930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hlc.2018.08.003
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