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Binding of the human antioxidation protein α(1)-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro

Heparin and heparan sulfate (HS) are linear sulfated disaccharide polymers. Heparin is found mainly in mast cells, while heparan sulfate is found in connective tissue, extracellular matrix and on cell membranes in most tissues. α(1)-microglobulin (A1M) is a ubiquitous protein with thiol-dependent an...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Bergwik, Jesper, Kristiansson, Amanda, Larsson, Jörgen, Ekström, Simon, Åkerström, Bo, Allhorn, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900767/
https://ncbi.nlm.nih.gov/pubmed/33607500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101892
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