Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors

Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells. This non-inflamed phenotype is likely responsible for the lack of sensitivity of prostate cancer patients to immune...

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Vydáno v:Mol Ther Oncolytics
Hlavní autoři: Annels, Nicola E., Simpson, Guy R., Denyer, Mick, Arif, Mehreen, Coffey, Matt, Melcher, Alan, Harrington, Kevin, Vile, Richard, Pandha, Hardev
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900644/
https://ncbi.nlm.nih.gov/pubmed/33665363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.09.010
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