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Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints

Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is commonly proposed as the mechanism by which DSBs cause deletion mutations, details such as the specific DNA repair errors a...

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Bibliografski detalji
Izdano u:iScience
Glavni autori: Lakshmanan, Lakshmi Narayanan, Yee, Zhuangli, Halliwell, Barry, Gruber, Jan, Gunawan, Rudiyanto
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900216/
https://ncbi.nlm.nih.gov/pubmed/33665557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102138
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