Complex biology of constitutional ring chromosomes structure and (in)stability revealed by somatic cell reprogramming

Human ring chromosomes are often unstable during mitosis, and daughter cells can be partially or completely aneuploid. We studied the mitotic stability of four ring chromosomes, 8, 13, 18, and 22, in long-term cultures of skin fibroblasts and induced pluripotent stem cells (iPSCs) by GTG karyotyping...

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Udgivet i:Sci Rep
Main Authors: Nikitina, T. V., Kashevarova, A. A., Gridina, M. M., Lopatkina, M. E., Khabarova, A. A., Yakovleva, Yu. S., Menzorov, A. G., Minina, Yu. A., Pristyazhnyuk, I. E., Vasilyev, S. A., Fedotov, D. A., Serov, O. L., Lebedev, I. N.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900208/
https://ncbi.nlm.nih.gov/pubmed/33619287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83399-3
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