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Autophagosome maturation stymied by SARS-CoV-2

Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex.

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Cell
Prif Awduron: Yim, Willa Wen-You, Mizushima, Noboru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Inc. 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898975/
https://ncbi.nlm.nih.gov/pubmed/33621488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.02.002
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