Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion

BACKGROUND: Multimerin 1 (human: MMRN1, mouse: Mmrn1) is a homopolymeric, adhesive, platelet and endothelial protein that binds to von Willebrand factor and enhances platelet adhesion to fibrillar collagen ex vivo. OBJECTIVES: To examine the impact of Mmrn1 deficiency on platelet adhesive function,...

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Publié dans:J Thromb Haemost
Auteurs principaux: Leatherdale, Alexander, Parker, D’Andra, Tasneem, Subia, Wang, Yiming, Bihan, Dominique, Bonna, Arkadiusz, Hamaia, Samir W., Gross, Peter L., Ni, Heyu, Doble, Bradley W., Lillicrap, David, Farndale, Richard W., Hayward, Catherine P. M.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898486/
https://ncbi.nlm.nih.gov/pubmed/33179420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15171
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