Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ

UDP-glucuronosyltransferase 1A1 (UGT1A1) is an essential enzyme in mammals that is responsible for detoxification and metabolic clearance of the endogenous toxin bilirubin and a variety of xenobiotics, including some crucial therapeutic drugs. Discovery of potent and safe UGT1A1 inducers will provid...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhu, Ya-Di, Guan, Xiao-Qing, Chen, Jing, Peng, Sheng, Finel, Moshe, Zhao, Ying-Yuan, Wang, Rui-Min, Bi, Hui-Chang, Lei, Ming, Wang, Dan-Dan, Ge, Guang-Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897654/
https://ncbi.nlm.nih.gov/pubmed/33628187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.628314
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