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Bilirubin Glucuronidation Revisited: Proper Assay Conditions to Estimate Enzyme Kinetics with Recombinant UGT1A1

Bilirubin, an end product of heme catabolism, is primarily eliminated via glucuronic acid conjugation by UGT1A1. Impaired bilirubin conjugation, caused by inhibition of UGT1A1, can result in clinical consequences, including jaundice and kernicterus. Thus, evaluation of the ability of new drug candid...

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Detalhes bibliográficos
Main Authors: Zhou, Jin, Tracy, Timothy S., Remmel, Rory P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967393/
https://ncbi.nlm.nih.gov/pubmed/20668247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.033829
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