Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2

Recent studies suggest that synaptic lysophosphatidic acids (LPAs) augment glutamate-dependent cortical excitability and sensory information processing in mice and humans via presynaptic LPAR2 activation. Here, we studied the consequences of LPAR2 deletion or antagonism on various aspects of cogniti...

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Detalles Bibliográficos
Publicado en:Cell Mol Life Sci
Main Authors: Fischer, Caroline, Endle, Heiko, Schumann, Lana, Wilken-Schmitz, Annett, Kaiser, Julia, Gerber, Susanne, Vogelaar, Christina F., Schmidt, Mirko H. H., Nitsch, Robert, Snodgrass, Isabel, Thomas, Dominique, Vogt, Johannes, Tegeder, Irmgard
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2020
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897625/
https://ncbi.nlm.nih.gov/pubmed/32468095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03553-4
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