Pentapeptide repeat protein QnrB1 requires ATP hydrolysis to rejuvenate poisoned gyrase complexes

DNA gyrase, a type II topoisomerase found predominantly in bacteria, is the target for a variety of ‘poisons’, namely natural product toxins (e.g. albicidin, microcin B17) and clinically important synthetic molecules (e.g. fluoroquinolones). Resistance to both groups can be mediated by pentapeptide...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Mazurek, Łukasz, Ghilarov, Dmitry, Michalczyk, Elizabeth, Pakosz, Zuzanna, Metelev, Mikhail, Czyszczoń, Wojciech, Wawro, Karolina, Behroz, Iraj, Dubiley, Svetlana, Süssmuth, Roderich D, Heddle, Jonathan G
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897471/
https://ncbi.nlm.nih.gov/pubmed/33434265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1266
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