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Defining New Chemical Space for Drug Penetration into Gram-Negative Bacteria

We live in the era of antibiotic resistance, and this problem will progressively worsen if no new solutions emerge. In particular, Gram-negative pathogens present both biological and chemical challenges that hinder the discovery of new antibacterial drugs. First, these bacteria are protected from a...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Zhao, Shibin, Adamiak, Justyna W., Bonifay, Vincent, Mehla, Jitender, Zgurskaya, Helen I., Tan, Derek S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897441/
https://ncbi.nlm.nih.gov/pubmed/33199906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00674-6
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