Deficiency of Stat1 in CD11c(+) Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet

CD11c(+) macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for MDC polarization into the M1-like phenotype. Here, we e...

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Udgivet i:Diabetes
Main Authors: Antony, Antu, Lian, Zeqin, Perrard, Xiaoyuan Dai, Perrard, Jerry, Liu, Hua, Cox, Aaron R., Saha, Pradip, Hennighausen, Lothar, Hartig, Sean M., Ballantyne, Christie M., Wu, Huaizhu
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2021
Fag:
Obesity Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897343/
https://ncbi.nlm.nih.gov/pubmed/33323395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0634
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