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Benchmarking computational doublet-detection methods for single-cell RNA sequencing data

In single-cell RNA sequencing (scRNA-seq), doublets form when two cells are encapsulated into one reaction volume. The existence of doublets, which appear as but are not real cells, is a key confounder in scRNA-seq data analysis. Computational methods have been developed to detect doublets in scRNA-...

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Vydáno v:Cell Syst
Hlavní autoři: Xi, Nan Miles, Li, Jingyi Jessica
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897250/
https://ncbi.nlm.nih.gov/pubmed/33338399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.11.008
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