Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP

The RNA polymerase inhibitor favipiravir is currently in clinical trials as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), despite limited information about the molecular basis for its activity. Here we report the structure of favipiravir ribonucleoside...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Naydenova, Katerina, Muir, Kyle W., Wu, Long-Fei, Zhang, Ziguo, Coscia, Francesca, Peet, Mathew J., Castro-Hartmann, Pablo, Qian, Pu, Sader, Kasim, Dent, Kyle, Kimanius, Dari, Sutherland, John D., Löwe, Jan, Barford, David, Russo, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896311/
https://ncbi.nlm.nih.gov/pubmed/33526596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021946118
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