Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver

OBJECTIVE: Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 diabetes (T2D). We here examined in vivo effects of...

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Bibliographic Details
Published in:PLoS One
Main Authors: Khatib Shahidi, Roxana, M. Hoffmann, Jenny, Hedjazifar, Shahram, Bonnet, Laurianne, K. Baboota, Ritesh, Heasman, Stephanie, Church, Christopher, Elias, Ivet, Bosch, Fatima, Boucher, Jeremie, Hammarstedt, Ann, Smith, Ulf
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895349/
https://ncbi.nlm.nih.gov/pubmed/33606810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0247300
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