BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

OBJECTIVE: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. Here, we exam...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Hoffmann, Jenny M., Grünberg, John R., Hammarstedt, Ann, Kroon, Tobias, Greiner, Thomas U., Maurer, Stefanie, Elias, Ivet, Palsdottir, Vilborg, Bosch, Fatima, Boucher, Jeremie, Hedjazifar, Shahram, Smith, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933264/
https://ncbi.nlm.nih.gov/pubmed/32029225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.11.016
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