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Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action
Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes. Imeglimin, a novel first-in-class small molecule tetrahydrotriazine drug candidate, improves glycemia and GSIS in preclinic...
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| Publicat a: | PLoS One |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7894908/ https://ncbi.nlm.nih.gov/pubmed/33606677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241651 |
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