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Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action
Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes. Imeglimin, a novel first-in-class small molecule tetrahydrotriazine drug candidate, improves glycemia and GSIS in preclinic...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7894908/ https://ncbi.nlm.nih.gov/pubmed/33606677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241651 |
| Oznake: |
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