Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism

CONTEXT: Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. OBJECTIVE: To clarify the potential mechanism for poor oral bioavaila...

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Dades bibliogràfiques
Publicat a:Pharm Biol
Autors principals: Shang, Haihua, Wang, Ze, Ma, Hong, Sun, Yinghui, Ci, Xiaoyan, Gu, Yuan, Liu, Changxiao, Si, Duanyun
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894426/
https://ncbi.nlm.nih.gov/pubmed/33595422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13880209.2021.1871634
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