Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis

BACKGROUND: The integrin VLA-4 (α4β1) plays an important role in leukocyte trafficking. This study investigated the efficacy of a novel topical α4β1 integrin inhibitor (GW559090, GW) in a mouse model for non-infectious posterior uveitis (experimental autoimmune uveitis; EAU) and its effect on intrao...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Chen, Yi Hsing, Eskandarpour, Malihe, Zhang, Xiaozhe, Galatowicz, Grazyna, Greenwood, John, Lightman, Sue, Calder, Virginia
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893745/
https://ncbi.nlm.nih.gov/pubmed/33602234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02080-8
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