Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT

BACKGROUND: Non-infectious uveitis can cause chronic relapsing and remitting ocular inflammation, which may require high dose systemic immunosuppression to prevent severe sight loss. It has been classically described as an autoimmune disease, mediated by pro-inflammatory Th1 and Th17 T-cell subsets....

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Gilbert, Rose M., Zhang, Xiaozhe, Sampson, Robert D., Ehrenstein, Michael R., Nguyen, Dao X., Chaudhry, Mahid, Mein, Charles, Mahmud, Nadiya, Galatowicz, Grazyna, Tomkins-Netzer, Oren, Calder, Virginia L., Lightman, Sue
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943505/
https://ncbi.nlm.nih.gov/pubmed/29774027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00907
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