Population differences in vaccine responses (POPVAC): scientific rationale and cross-cutting analyses for three linked, randomised controlled trials assessing the role, reversibility and mediators of immunomodulation by chronic infections in the tropics

INTRODUCTION: Vaccine-specific immune responses vary between populations and are often impaired in low income, rural settings. Drivers of these differences are not fully elucidated, hampering identification of strategies for optimising vaccine effectiveness. We hypothesise that urban–rural (and regi...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Nkurunungi, Gyaviira, Zirimenya, Ludoviko, Natukunda, Agnes, Nassuuna, Jacent, Oduru, Gloria, Ninsiima, Caroline, Zziwa, Christopher, Akello, Florence, Kizindo, Robert, Akello, Mirriam, Kaleebu, Pontiano, Wajja, Anne, Luzze, Henry, Cose, Stephen, Webb, Emily, Elliott, Alison M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Infectious Diseases
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893603/
https://ncbi.nlm.nih.gov/pubmed/33593767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2020-040425
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