Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells

Several natural products have been demonstrated to both enhance the anti-tumor efficacy and alleviate the side effects of conventional chemotherapy drugs. Rhein, a main constituent of the Chinese herb rhubarb, has been shown to induce apoptosis in various cancer types. However, the exact pharmacolog...

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Bibliografiske detaljer
Udgivet i:Int J Biol Sci
Main Authors: Liu, Yuhui, Shi, Chengjian, He, Zheng, Zhu, Feng, Wang, Min, He, Ruizhi, Zhao, Chunle, Shi, Xiuhui, Zhou, Min, Pan, Shutao, Gao, Yang, Li, Xu, Qin, Renyi
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893580/
https://ncbi.nlm.nih.gov/pubmed/33613115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.49514
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