Patient-derived xenografts and organoids model therapy response in prostate cancer

Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe an androgen-dependent PCa patient-derived xenograft (PDX) model from treatment-naïve, soft tissue metastasis (PNPCa). RNA and who...

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Publicado en:Nat Commun
Autores principales: Karkampouna, Sofia, La Manna, Federico, Benjak, Andrej, Kiener, Mirjam, De Menna, Marta, Zoni, Eugenio, Grosjean, Joël, Klima, Irena, Garofoli, Andrea, Bolis, Marco, Vallerga, Arianna, Theurillat, Jean-Philippe, De Filippo, Maria R., Genitsch, Vera, Keller, David, Booij, Tijmen H., Stirnimann, Christian U., Eng, Kenneth, Sboner, Andrea, Ng, Charlotte K. Y., Piscuoglio, Salvatore, Gray, Peter C., Spahn, Martin, Rubin, Mark A., Thalmann, George N., Kruithof-de Julio, Marianna
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892572/
https://ncbi.nlm.nih.gov/pubmed/33602919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21300-6
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