Patient-derived xenografts and organoids model therapy response in prostate cancer

Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe an androgen-dependent PCa patient-derived xenograft (PDX) model from treatment-naïve, soft tissue metastasis (PNPCa). RNA and who...

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Publicat a:Nat Commun
Autors principals: Karkampouna, Sofia, La Manna, Federico, Benjak, Andrej, Kiener, Mirjam, De Menna, Marta, Zoni, Eugenio, Grosjean, Joël, Klima, Irena, Garofoli, Andrea, Bolis, Marco, Vallerga, Arianna, Theurillat, Jean-Philippe, De Filippo, Maria R., Genitsch, Vera, Keller, David, Booij, Tijmen H., Stirnimann, Christian U., Eng, Kenneth, Sboner, Andrea, Ng, Charlotte K. Y., Piscuoglio, Salvatore, Gray, Peter C., Spahn, Martin, Rubin, Mark A., Thalmann, George N., Kruithof-de Julio, Marianna
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892572/
https://ncbi.nlm.nih.gov/pubmed/33602919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21300-6
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