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Biosynthesis of the nuclear factor of activated T cells inhibitor NFAT-133 in Streptomyces pactum
NFAT-133 is a Streptomyces-derived aromatic polyketide compound with immunosuppressive, antidiabetic, and anti-trypanosomal activities. It inhibits transcription mediated by nuclear factor of activated T cells (NFAT), leading to the suppression of interleukin-2 expression and T cell proliferation. I...
Shranjeno v:
| izdano v: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7891853/ https://ncbi.nlm.nih.gov/pubmed/33284588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00775 |
| Oznake: |
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