Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type 2 diabetes. While many of these patients eventually will need treatment with insulin, little is known about the effects of insulin treatment on hist...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Jensen, Victoria Svop, Fledelius, Christian, Zachodnik, Christina, Damgaard, Jesper, Nygaard, Helle, Tornqvist, Kristina Steinicke, Kirk, Rikke Kaae, Viuff, Birgitte Martine, Wulff, Erik Max, Lykkesfeldt, Jens, Hvid, Henning
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890970/
https://ncbi.nlm.nih.gov/pubmed/33596938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02729-1
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