Tumour extracellular vesicle‐derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement‐dependent cytotoxicity of tumour cells

The complement system is involved in the immunosurveillance of pathogens and tumour cells. Proteomic profiling revealed that extracellular vesicles (EVs) released by metastatic hepatocellular carcinoma (HCC) cells contained a significant number of complement proteins. Complement Factor H (CFH), an a...

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Veröffentlicht in:J Extracell Vesicles
Hauptverfasser: Mao, Xiaowen, Zhou, Longyin, Tey, Sze Keong, Ma, Angel Po Yee, Yeung, Cherlie Lot Sum, Ng, Tung Him, Wong, Samuel Wan Ki, Liu, Bonnie Hei Man, Fung, Yi Man Eva, Patz, Edward F., Cao, Peihua, Gao, Yi, Yam, Judy Wai Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890557/
https://ncbi.nlm.nih.gov/pubmed/33708358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jev2.12031
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